The four county study of childhood cancer: clusters in context

Autor:	P, Reynolds, D F, Smith, E, Satariano, D O, Nelson, L R, Goldman, R R, Neutra
Rok vydání:	1996
Předmět:	Adolescent Incidence Infant Newborn Infant Environmental Exposure California Residence Characteristics Child Preschool Neoplasms Population Surveillance Multivariate Analysis Cluster Analysis Humans Regression Analysis Poisson Distribution Agrochemicals Child
Zdroj:	Statistics in medicine. 15(7-9)
ISSN:	0277-6715
Popis:	Observations of childhood 'cancer clusters' in small communities in central California prompted us to examine the distribution of childhood cancer in communities throughout the region to see if the overall cancer rate or the distribution of 'cancer clusters' was unusual for agricultural towns where pesticide exposure might be elevated. The distribution of rates was evaluated using a variety of methods: comparison of rates to the regional average, evaluation of the empirical observed versus expected Poisson distribution of events, and multivariate modelling using Poisson regression. These analyses suggest that there were no previously undiscovered communities with excess rates, although the index community which prompted the initial investigation does stand out as unusual. We discuss the impact of a range of forces of morbidity on the likelihood of 'cancer clusters' and the distributions of observed and expected numbers of cancers in a population of locales.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::1e67091077f1518a8d05ae0732b2f97f https://pubmed.ncbi.nlm.nih.gov/9132896 Zobrazit plný text záznamu Plný text