Viral markers in nasopharyngeal carcinoma: A systematic review and meta-analysis on the detection of p16

Autor:	Tristan, Tham, Rosalie, Machado, Daniel P, Russo, Saori Wendy, Herman, Sushma, Teegala, Peter, Costantino
Rok vydání:	2020
Předmět:	Epstein-Barr Virus Infections Herpesvirus 4 Human Nasopharyngeal Carcinoma Papillomavirus Infections Humans Nasopharyngeal Neoplasms Alphapapillomavirus Prognosis Biomarkers Cyclin-Dependent Kinase Inhibitor p16
Zdroj:	American journal of otolaryngology. 42(1)
ISSN:	1532-818X
Popis:	This study aimed to conduct a meta-analysis to investigate the distribution of EBV and HPV stratified according to histological NPC type.We performed a meta-analysis to produce pooled prevalence estimates in a random-effects model. We also performed calculations for attributable fractions of viral combinations in NPC, stratified according to histological type.There was a higher prevalence of HPV DNA in WHO Type I (34.4%) versus WHO Type II/III (18.4%). The attributable fractions of WHO Type I NPC was predominantly double negative EBV(-) HPV(-) NPC (56.4%), and EBV(-) HPV(+) NPC (21.5%), in contrast to the predominant infection in WHO Type II/III which was EBV(+) HPV(-) NPC (87.5%). Co-infection of both EBV and HPV was uncommon, and double-negative infection was more common in WHO Type I NPC.A significant proportion of WHO Type I NPC was either double-negative EBV(-)HPV(-) or EBV(-)HPV(+).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::1e6479ab99788f8b7a170b0d264f1fbc https://pubmed.ncbi.nlm.nih.gov/33202328 Zobrazit plný text záznamu Full Text from ScienceDirect