Hepatitis C in Peru: risk factors for infection, potential iatrogenic transmission, and genotype distribution
| Autor: | J L, Sanchez, M H, Sjogren, J D, Callahan, D M, Watts, C, Lucas, M, Abdel-Hamid, N T, Constantine, K C, Hyams, S, Hinostroza, R, Figueroa-Barrios, J C, Cuthie |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Adolescent Genotype Reverse Transcriptase Polymerase Chain Reaction Iatrogenic Disease Age Factors Infant Newborn Infant Enzyme-Linked Immunosorbent Assay Hepacivirus Hepatitis C Antibodies Hepatitis C Polymerase Chain Reaction Sex Factors Risk Factors Seroepidemiologic Studies Child Preschool Peru Humans Female Child |
| Zdroj: | The American journal of tropical medicine and hygiene. 63(5-6) |
| ISSN: | 0002-9637 |
| Popis: | A large seroepidemiologic and genotyping study of hepatitis C virus (HCV) was conducted in Lima, Peru, during the periods of 1986 to 1993 (cohort A) and 1994 (cohort B). Anti-HCV seroprevalence rates were 15.6% (216 of 1,389) and 11.7% (168 of 1,438), respectively. Low rates were seen among volunteer blood donors (1.1% and 0.8%). Anti-HCV rates were much higher among patients undergoing hemodialysis (43.7% and 59.3%), hemophiliacs (60.0% and 83.3%), in those more than 39 years old (18.2% and 26.0%), in females (25.0% and 27.4%), and in less-educated persons (16.9%). Age- and gender-adjusted risk factors in cohort B included blood transfusion history (adjusted odds ratio [AOR] = 29.8), prior organ transplantation (AOR = 9.1) or a history of hepatitis (AOR = 4.9), previous hospitalization (AOR = 3.7), a history of intravenous drug use (AOR = 3.5), prior major surgery (AOR = 2.6), a history of acupuncture (AOR = 2.1), previous dental procedures (AOR = 1.2), and prior medical injections (AOR = 1.04). The most prevalent HCV genotype was type 1 (86%), followed by type 3 (10%) and type 2 (2%). Transmission through unsafe injection-related and medical/dental procedures appears to play an important role in HCV infection among Peruvians. |
| Databáze: | OpenAIRE |
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