| Autor: |
João P L, Guerra, Clement E, Blanchet, Bruno J C, Vieira, Ana V, Almeida, João C, Waerenborgh, Nykola C, Jones, Søren V, Hoffmann, Pedro, Tavares, Alice S, Pereira |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
International journal of molecular sciences. 23(9) |
| ISSN: |
1422-0067 |
| Popis: |
DNA-binding proteins from starved cells (Dps) are homododecameric nanocages, with N- and C-terminal tail extensions of variable length and amino acid composition. They accumulate iron in the form of a ferrihydrite mineral core and are capable of binding to and compacting DNA, forming low- and high-order condensates. This dual activity is designed to protect DNA from oxidative stress, resulting from Fenton chemistry or radiation exposure. In most Dps proteins, the DNA-binding properties stem from the N-terminal tail extensions. We explored the structural characteristics of a Dps from |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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