Maternal chronic hypoxia increases expression of genes regulating lung liquid movement and surfactant maturation in male fetuses in late gestation
| Autor: | Erin V, McGillick, Sandra, Orgeig, Beth J, Allison, Kirsty L, Brain, Youguo, Niu, Nozomi, Itani, Katie L, Skeffington, Andrew D, Kane, Emilio A, Herrera, Dino A, Giussani, Janna L, Morrison |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Jumonji Domain-Containing Histone Demethylases Pulmonary Surfactant-Associated Proteins Sheep Cystic Fibrosis Transmembrane Conductance Regulator respiratory system Fetal Hypoxia respiratory tract diseases Hypoxia-Inducible Factor-Proline Dioxygenases Pregnancy Basic Helix-Loop-Helix Transcription Factors Integrative Animals 11-beta-Hydroxysteroid Dehydrogenases Female Lung Heme Oxygenase-1 |
| Zdroj: | The Journal of physiology. 595(13) |
| ISSN: | 1469-7793 |
| Popis: | Chronic fetal hypoxaemia is a common pregnancy complication associated with intrauterine growth restriction that may influence respiratory outcome at birth. We investigated the effect of maternal chronic hypoxia for a month in late gestation on signalling pathways regulating fetal lung maturation and the transition to air-breathing at birth using isobaric hypoxic chambers without alterations to maternal food intake. Maternal chronic hypoxia in late gestation increases fetal lung expression of genes regulating hypoxia signalling, lung liquid reabsorption and surfactant maturation, which may be an adaptive response in preparation for the successful transition to air-breathing at birth. In contrast to other models of chronic fetal hypoxaemia, late gestation onset fetal hypoxaemia promotes molecular regulation of fetal lung maturation. This suggests a differential effect of timing and duration of fetal chronic hypoxaemia on fetal lung maturation, which supports the heterogeneity observed in respiratory outcomes in newborns following exposure to chronic hypoxaemia in utero.Chronic fetal hypoxaemia is a common pregnancy complication that may arise from maternal, placental and/or fetal factors. Respiratory outcome of the infant at birth likely depends on the duration, timing and severity of the hypoxaemic insult. We have isolated the effect of maternal chronic hypoxia (MCH) for a month in late gestation on fetal lung development. Pregnant ewes were exposed to normoxia (21% O |
| Databáze: | OpenAIRE |
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