| Autor: |
Angela Isabel, Tissone, Varinia Beatriz, Vidal, Marcela Silvia, Nadal, German, Mato, Yimy, Amarillo |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Journal of neurophysiology. 126(2) |
| ISSN: |
1522-1598 |
| Popis: |
Membrane potential oscillations of thalamocortical (TC) neurons are believed to be involved in the generation and maintenance of brain rhythms that underlie global physiological and pathological brain states. These membrane potential oscillations depend on the synaptic interactions of TC neurons and their intrinsic electrical properties. These oscillations may be also shaped by increased output responses at a preferred frequency, known as intrinsic neuronal resonance. Here, we combine electrophysiological recordings in mouse brain slices, modern pharmacological tools, dynamic clamp, and computational modeling to study the ionic mechanisms that generate and modulate TC neuron resonance. We confirm findings of pioneering studies showing that most TC neurons display resonance that results from the interaction of the slow inactivation of the low-threshold calcium current |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
