| Autor: |
Xiahui, Peng, Qiang, Zhuang, Dongming, Peng, Qiuli, Dong, Lini, Tan, Feipeng, Jiao, Linqi, Liu, Jingyu, Liu, Chenxi, Zhao, Xiaomei, Wang |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
Iranian Journal of Pharmaceutical Research : IJPR |
| ISSN: |
1735-0328 |
| Popis: |
In this paper, carbon nanotubes (CNTs) were added into chitosan (CS) hydrogels in the form of chitosan modified CNTs (CS-CNTs) composites to prepare carbon nanotubes hydrogels (CNTs-GEL). The products, named CS-MWCNTs, were characterized by scanning electron microscope (SEM) and Fourier transform infrared (FTIR) spectroscopy. Swelling properties and effect of pH on controlled release performance of the two kinds of hydrogels, CNTs- GEL and pure chitosan hydrogels without CNTs (GEL), were investigated respectively. The results showed that CNTs-GEL possess better controlled release performance than GEL. The releasing equilibrium time of CNTs-GEL was longer than that of GEL in both pH = w7.4 and pH=1.2 conditions, although the release ratios of the model drug are similar in the same pH buffer solutions. It is found that release kinetics is better fitted Ritger-Peppas empirical model indicating a fick-diffusion process in pH = 1.2, while in pH = 7.4 it was non-fick diffusion involving surface diffusion and corrosion diffusion processes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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