| Autor: |
Starkl, Philipp, Watzenboeck, Martin L., Popov, Lauren M., Zahalka, Sophie, Hladik, Anastasiya, Lakovits, Karin, Radhouani, Mariem, Haschemi, Arvand, Marichal, Thomas, Reber, Laurent L., Gaudenzio, Nicolas, Sibilano, Riccardo, Stulik, Lukas, Fontaine, Frédéric, Mueller, André C., Amieva, Manuel R., Galli, Stephen J., Knapp, Sylvia |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Immunity |
| Popis: |
Allergies are considered to represent mal-directed type 2 immune responses against mostly innocuous exogenous compounds. Immunoglobulin E (IgE) antibodies are a characteristic feature of allergies and mediate hypersensitivity against allergens through activation of effector cells, particularly mast cells (MCs). While any physiologic functions of this dangerous branch of immunity have remained enigmatic, recent evidence shows that allergic immune reactions can help to protect against the toxicity of venoms. Because bacteria represent a potent alternative source of toxins, we assessed the possible role of allergy-like type 2 immunity in antibacterial host defense. We discovered that the adaptive immune response against Staphylococcus aureus (SA) skin infection substantially improved systemic host defense against secondary SA infections in mice. Moreover, this acquired protection depended on IgE effector mechanisms and MCs. Importantly, our results reveal a previously unknown physiologic function of allergic immune responses, IgEs and MCs in host defense against a pathogenic bacterium. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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