| Autor: |
E, Gómez Martínez, S, Borrás Pallé, F, Valls Grima, L L, Miralles Serrano, L, Moltó Guillamont, M M, Jarabo Bueno, V, Gómez Casals, V, Valentín Segura |
| Rok vydání: |
2007 |
| Předmět: |
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| Zdroj: |
Medicina intensiva. 31(3) |
| ISSN: |
0210-5691 |
| Popis: |
To assess the inflammatory state in patients with persistent atrial fibrillation and to determine the predictive value in the success of cardioversion and recurrence at 30 days.Prospective observational case-control study.We included consecutively 49 patients with atrial fibrillation previously to scheduled electrical cardioversion in Coronary Care Unit. Clinical and echocardiographic variables were registered and High-sensivity C-reactive protein, interleukin-1beta, interleukin-6 and Tumour Necrosis Factor-alpha were measured. At 30-days follow-up, rhythm and biomarkers were reassessed. As control groups, we recruited 27 healthy volunteers and 16 patients matched for age, gender and cardiovascular risk factors.Median age was 66 +/- 10 years and 38% were women. All the markers were higher in patients than in both control groups (p0.05). FNT-alpha and Interleukin-6 levels were higher in non-cardiovertors but only an enlarged atria was related to unsuccessful cardioversion (p = 0.036). High-sensivity C-reactive protein values in the higher cuartile tended to be related to recurrence of persistent atrial fibrillation (p = 0.06).There is an increased inflammatory state in patients with atrial fibrillation. FNT-alpha and Interleukin-6 levels were increased in non-cardiovertors, but no biomarker was associated with success of cardioversion or rhythm state at 30-days. However, higher levels of hs-CRP showed a trend to be related to recurrence of atrial fibrillation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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