| Autor: |
A, Girdhar, B K, Girdhar, G, Ramu, R K, Lavania, K V, Desikan |
| Rok vydání: |
2017 |
| Zdroj: |
Indian journal of dermatology, venereology and leprology. 51(4) |
| ISSN: |
0973-3922 |
| Popis: |
To study the effect of prothionamide. on the infectivity of untreated lepromatous patients 20 cases were randomly given either 250 mg or 500 mg prothionamide monotherapy daily for 2 months. All patients tolerated the drug well. Clinical improvement with healing of mucosal ulcers was seen in 13 of the 16 cases. Nasal smears become negative in all the cases within 2 months. Mouse footpad inoculation done from biopsy specimens/skin scrape suspension- s became non infective to mice in all the cases within the trial period. There was a substantial reduction in ,the MI and histopathology showed complete fragmentation of the bacilli with a significant increase in the lymphocyte content. The -findings suggest a rapid bactericidal effect and a similar, use fullness on both the doses of the drug for the treatment of multibacillary leprosy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
