| Autor: |
A, Sperfeld, G, Vietzke, F X, Kleber, A C, Ludolph |
| Jazyk: |
němčina |
| Rok vydání: |
1999 |
| Předmět: |
|
| Zdroj: |
Der Nervenarzt. 70(2) |
| ISSN: |
0028-2804 |
| Popis: |
Cardiopulmonary exercise testing (CPX) is a non-invasive method of recording quantitative data from gas exchange and ventilation for the evaluation of oxidative metabolism at rest and during exercise. Determination of oxygen uptake (VO2) and carbon dioxide output (VCO2) describes the activity of anaerobic vs aerobic metabolism. An incremental exercise test measuring gas exchange, ventilation and lactate release was performed in healthy volunteers and in patients suffering from mitochondrial disorders. At rest as well as during exercise patients with mitochondrial disorders differ from healthy subjects with regard to gas exchange and ventilation parameters. During exercise, the decreased oxygen utilization of skeletal muscle and early activation of anaerobic metabolism in these patients are mirrored by a reduced anaerobic threshold, reduced maximal oxygen uptake and reduced oxygen pulse. Our study shows that CPX is a sensitive and practical clinical screening method of investigating mitochondrial disorders. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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