The volume-regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING-p53 signaling

Autor:	Axel R, Concepcion, Larry E, Wagner, Jingjie, Zhu, Anthony Y, Tao, Jun, Yang, Alireza, Khodadadi-Jamayran, Yin-Hu, Wang, Menghan, Liu, Rebecca E, Rose, Drew R, Jones, William A, Coetzee, David I, Yule, Stefan, Feske
Rok vydání:	2021
Předmět:	Anions Mice Inbred C57BL Mice T-Lymphocytes Animals Membrane Proteins Calcium Female Nucleotides Cyclic Tumor Suppressor Protein p53 Dinucleoside Phosphates Ion Channels Signal Transduction
Zdroj:	Nature immunology. 23(2)
ISSN:	1529-2916
Popis:	The volume-regulated anion channel (VRAC) is formed by LRRC8 proteins and is responsible for the regulatory volume decrease (RVD) after hypotonic cell swelling. Besides chloride, VRAC transports other molecules, for example, immunomodulatory cyclic dinucleotides (CDNs) including 2'3'cGAMP. Here, we identify LRRC8C as a critical component of VRAC in T cells, where its deletion abolishes VRAC currents and RVD. T cells of Lrrc8c
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::1d70ea379ffa47c68558569a6962a71d https://pubmed.ncbi.nlm.nih.gov/35105986 Zobrazit plný text záznamu Full text from SpringerLink