| Autor: |
S, Belia, S, Fulle, S, Antonioli, A M, Salvatore, G, Fano |
| Rok vydání: |
1991 |
| Předmět: |
|
| Zdroj: |
Physiological chemistry and physics and medical NMR. 23(1) |
| ISSN: |
0748-6642 |
| Popis: |
The aim of this work is to examine if the membrane-bound Phospholipase C system is correlated with the differentiative action of Nerve Growth Factor in PC12 cells. We found that the activity of membrane-bound Phospholipase C system increased with the presence of Nerve Growth Factor at two different phases. The early phase occurs during the first minutes after the formation of Nerve Growth Factor-receptor complex and it is completed within one hour. The later phase starts two hours after Nerve Growth Factor introduction and lasts for at least a total of 48 hours. The inositol-triphosphate levels measured in intact cells by radioimmunoassay show the same pattern of activation. We think that this dual response to Nerve Growth Factor could be due to either a double separated activation of the same enzyme or the presence of two different forms of membrane-bound Phospholipase C. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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