| Autor: |
E J, Thonar, K, Masuda, M E, Lenz, H J, Hauselmann, K E, Kuettner, D H, Manicourt |
| Rok vydání: |
1995 |
| Předmět: |
|
| Zdroj: |
The Journal of rheumatology. Supplement. 43 |
| ISSN: |
0380-0903 |
| Popis: |
Serum levels of several molecules originating from joints and cartilages have been shown to rise during the preradiological stages of osteoarthritis (OA). Using a dog model of posttraumatic OA, we have shown that serum levels of markers of aggrecan degradation (antigenic keratan sulfate) and synovial proliferation/metabolism (hyaluronan) rise within 1-2 weeks after the injury and remain elevated for at least 13 weeks. These changes, which precede the development of OA lesions, are consistent with the view that traumatic injury to a single synovial joint gives rise to a state of hypermetabolism that is local at first but becomes systemic with time. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
