Immunologic and toxicologic study of disaccharide tripeptide glycerol dipalmitoyl: a new lipophilic immunomodulator

Autor:	G J, Vosika, D A, Cornelius, J A, Bennek, J R, Sadlik, C W, Gilbert
Rok vydání:	1990
Předmět:	Cytotoxicity Immunologic Immunity Cellular Mice Inbred BALB C Fever Palmitates Palmitic Acids Macrophage Activation Disaccharides Biological Factors Mice Adjuvants Immunologic Liposomes Animals Cytokines Humans Rabbits Sarcoma Experimental Acetylmuramyl-Alanyl-Isoglutamine
Zdroj:	Molecular biotherapy. 2(1)
ISSN:	0952-8172
Popis:	A new lipophilic immunomodulator, disaccharide tripeptide glycerol dipalmitoyl (DTP-GDP), has been synthesized and evaluated for its immunologic activity and toxicology. DTP-GDP alone or in liposomes is more effective as an adjuvant and in activating macrophages compared with muramyldipeptide (MDP). Preclinical studies demonstrate no evidence of toxicity, including vasculitis. DTP-GDP in liposomes has shown antitumor activity in phase I clinical trials.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::1c9b56efe230054a625bee03ddb5126c https://pubmed.ncbi.nlm.nih.gov/2185794 Zobrazit plný text záznamu