| Autor: |
A V, Ermakov, M S, Kon'kova, S V, Kostiuk, T D, Smirnova, L V, Kameneva, R V, Veĭko, I Iu, Kubasova, L N, Liubchenko, N N, Veĭko |
| Rok vydání: |
2010 |
| Předmět: |
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| Zdroj: |
Radiatsionnaia biologiia, radioecologiia. 50(1) |
| ISSN: |
0869-8031 |
| Popis: |
Transposition and mutual approaching of pericentromeric loci 1q12 of homological chromosomes from the nuclear membrane towards the nuclear centre as well as activation of the chromosomal nucleolus-forming regions (NFR) are observed in human mesenchymal stem cells (hMSCs) as an initial stages of the adaptive response (AR) after exposure to low doses of X-radiation (10 cGy). All these reactions are also induced after addition of cultivation medium from irradiated cells to intact bystander-cells and this phenomenon called bystander effect (BE). Recently the same AR and BE induction results were obtained for human G0-lymphocytes. All these data indicate the existence of universal reaction of homological chromosome loci transposition which was revealed during AR development in differentiated (lymphocytes) and non-differentiated (hMSCs) and also it shows possibility of radiational BE development in suspension and monolayer cell cultures upon addition of stress-signalization factors in incubation medium. We suppose that these factors are extracellular genome DNA fragments apoptotic cells. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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