| Autor: |
M F, Denisenko, L N, Belovskaia, V A, Soldatenkov, T N, Smirnova, I V, Filippovich |
| Rok vydání: |
1987 |
| Předmět: |
|
| Zdroj: |
Radiobiologiia. 27(6) |
| ISSN: |
0033-8192 |
| Popis: |
A decrease in the endogenous NAD content that occurs immediately after gamma-irradiation of thymus lymphocytes is attributed to activation of poly (ADP-ribosylation) and not to changes in the activity of NAD-glycohydrolase and/or to the release of NAD from cells. The addition of benzamide 60 min before irradiation prevents the postirradiation drop of the NAD level and produces a radioprotective effect. At the same time, benzamide inhibits nuclear superhelix DNA repair and causes an average of 40 per cent decrease in the activity of DNA ligases I and II. The authors discuss the idea that the content of intracellular NAD in thymocytes is a critical factor responsible for the vitality of these cells. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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