[STUDYING NEUROPROTECTIVE ACTIVITY OF GABA CONJUGATE WITH ARACHIDONIC ACID UNDER CONDITIONS OF LOCAL PERMANENT BRAIN ISCHEMIA IN RATS]

Autor: N R, Mirzoyan, N G, Hostikyan, A G, Stepanyan, A A, Akopyan, K B, Alikhanyan, V S, Meliksetyan, N A, Bagdasaryan, N M, Gretskaya, V V, Bezuglov
Rok vydání: 2015
Předmět:
Zdroj: Eksperimental'naia i klinicheskaia farmakologiia. 78(6)
ISSN: 0869-2092
Popis: We have studied the effect of a GABA conjugate with arachidonic acid (AA) on the morphological state of rat brain tissues after left median cerebral artery occlusion. The results showed that a 6- and 12-day course administration of the GABA - AA conjugate at dose of 2 mg/kg (i.p.) in rats with this model of local permanent brain ischemia led to significant recovery processes in brain tissues. The tissue morphology pattern in the group of animals treated with the GABSA - AA conjugate for 12 days was almost identical to that in intact tissues.
Databáze: OpenAIRE