| Autor: |
T V, Davydova, M A, Gruden, V S, Kudrin, V B, Narkevich, L A, Vetrile, I A, Zakharova, R D E, Sewell |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Bulletin of experimental biology and medicine. 171(1) |
| ISSN: |
1573-8221 |
| Popis: |
We analyzed delayed effect of intranasal administration of anti-glutamate antibodies on mnestic function and tissue concentrations of neurotransmitters in the hippocampus and prefrontal cortex in aging C57BL/6 mice. It was found that after 14-day administration of anti-glutamate antibodies, improvement of the passive avoidance conditioning persisted for 7 days after the treatment was discontinued. In 7 days after discontinuation of treatment, increased content of dopamine and its metabolites as well as aspartic acid and taurine was observed in the hippocampus of mice treated with anti-glutamate antibodies. In the prefrontal cortex, administration of anti-glutamate antibodies had no effect on the levels of neurotransmitters, but increased the concentration of glutamate. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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