Novel Mutation in Syntaxin-Binding Protein 2 (STXBP2) Prevents IL-2-induced Natural Killer Cell Cytotoxicity
| Autor: | Saltzman, Rushani W., Monaco-Shawver, Linda, Zhang, Kejian, Sullivan, Kathleen E., Filipovich, Alexandra H., Orange, Jordan S. |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: | |
| Popis: | We have identified dizygotic twins with a novel syntaxin-binding protein 2 (STXBP2) mutation, where cytotoxicity cannot be restored with IL-2. This defines STXBP2 as an absolute requirement for NK cell cytotoxic function. |
| Databáze: | OpenAIRE |
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