| Autor: |
Oliver C J, Andrén, Tobias, Ingverud, Daniel, Hult, Joakim, Håkansson, Yalda, Bogestål, Josefin S, Caous, Kristina, Blom, Yuning, Zhang, Therese, Andersson, Emma, Pedersen, Camilla, Björn, Peter, Löwenhielm, Michael, Malkoch |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Advanced healthcare materials. 8(5) |
| ISSN: |
2192-2659 |
| Popis: |
A non-toxic hydrolytically fast-degradable antibacterial hydrogel is herein presented to preemptively treat surgical site infections during the first crucial 24 h period without relying on conventional antibiotics. The approach capitalizes on a two-component system that form antibacterial hydrogels within 1 min and consist of i) an amine functional linear-dendritic hybrid based on linear poly(ethylene glycol) and dendritic 2,2-bis(hydroxymethyl)propionic acid, and ii) a di-N-hydroxysuccinimide functional poly(ethylene glycol) cross-linker. Broad spectrum antibacterial effect is achieved by multivalent representation of catatonically charged β-alanine on the dendritic periphery of the linear dendritic component. The hydrogels can be applied readily in an in vivo setting using a two-component syringe delivery system and the mechanical properties can accurately be tuned in the range equivalent to fat tissue and cartilage (G' = 0.5-8 kPa). The antibacterial effect is demonstrated both in vitro toward a range of relevant bacterial strains and in an in vivo mouse model of surgical site infection. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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