| Autor: |
Yan, Zhou, Zhou-Lin, Zhong, Li-Lan, Li, Wei-Dong, Shen, Guo-Guang, Wu |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
Zhongguo shi yan xue ye xue za zhi. 22(2) |
| ISSN: |
1009-2137 |
| Popis: |
This study was aimed to investigate the detection and diagnosis of the neonatal alloimmune thrombocytopenia purpura (NAITP) caused by anti-HPA-5b antibody. The platelet count and clinical manifestation in the newborn were examined. The HPA-1-21bw genotypes of the newborn and her parents were detected by multiple-PCR and DNA sequencing. The HPA-specific antibody in the sera of newborn and her mother were detected and identified by flow cytometry (FCM) and monoclonal antibody-specific immobilization of platelet antigens (MAIPA). The results indicated that the clinical manifestations of the newborn were lighter. The HPA genotyping showed that the genotype of the newborn was HPA-5ab, while that of her mother and father were HPA-5aa and HPA-5ab, respectively. The antibody against the platelet of newborn's father existed in the newborn's mother sera. The HPA antibody of the mother was identified as anti-HPA-5b. It is concluded that the newborn with neonatal alloimmune thrombocytopenia purpura was caused by the antibody against HPA-5b. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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