Abundant glutamic acid decarboxylase (GAD)-reactive B cells in gad-antibody-associated neurological disorders

Autor:	Franziska S, Thaler, Anna L, Thaller, Michelle, Biljecki, Elisabeth, Schuh, Stephan, Winklmeier, Christoph F, Mahler, Ramona, Gerhards, Stefanie, Völk, Frauke, Schnorfeil, Marion, Subklewe, Reinhard, Hohlfeld, Tania, Kümpfel, Edgar, Meinl
Rok vydání:	2018
Předmět:	Adult Male B-Lymphocytes Adolescent Cerebellar Ataxia Glutamate Decarboxylase Plasma Cells Bone Marrow Cells Stiff-Person Syndrome Middle Aged Young Adult Case-Control Studies Immunoglobulin G Limbic Encephalitis Leukocytes Mononuclear Humans Female Aged Autoantibodies
Zdroj:	Annals of neurology. 85(3)
ISSN:	1531-8249
Popis:	High levels of antibodies against glutamic acid decarboxylase (GAD) are observed in patients with different neurological disorders, but cells producing these autoantibodies are largely unexplored. We detect circulating GAD-reactive B cells in peripheral blood that readily differentiate into antibody-producing cells. These cells are highly elevated in most patients with GAD-antibody-associated disorders (n = 15) compared to controls (n = 19). They mainly produce GAD65 antibodies of the IgG1 and IgG4 subclasses and are as abundant as B cells reactive for common recall antigens. Bone marrow cells represent an additional source of GAD antibodies. The identification of GAD-antibody-producing cells has implications for the selection of cell-specific biologics. ANN NEUROL 2019;85:448-454.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::1c0e6e89d86fa7e44653f49f6e8a9aec https://pubmed.ncbi.nlm.nih.gov/30635933 Zobrazit plný text záznamu Plný text