Autor: |
Franziska S, Thaler, Anna L, Thaller, Michelle, Biljecki, Elisabeth, Schuh, Stephan, Winklmeier, Christoph F, Mahler, Ramona, Gerhards, Stefanie, Völk, Frauke, Schnorfeil, Marion, Subklewe, Reinhard, Hohlfeld, Tania, Kümpfel, Edgar, Meinl |
Rok vydání: |
2018 |
Předmět: |
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Zdroj: |
Annals of neurology. 85(3) |
ISSN: |
1531-8249 |
Popis: |
High levels of antibodies against glutamic acid decarboxylase (GAD) are observed in patients with different neurological disorders, but cells producing these autoantibodies are largely unexplored. We detect circulating GAD-reactive B cells in peripheral blood that readily differentiate into antibody-producing cells. These cells are highly elevated in most patients with GAD-antibody-associated disorders (n = 15) compared to controls (n = 19). They mainly produce GAD65 antibodies of the IgG1 and IgG4 subclasses and are as abundant as B cells reactive for common recall antigens. Bone marrow cells represent an additional source of GAD antibodies. The identification of GAD-antibody-producing cells has implications for the selection of cell-specific biologics. ANN NEUROL 2019;85:448-454. |
Databáze: |
OpenAIRE |
Externí odkaz: |
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