Interleukin-8 levels and granulocyte counts in cervical mucus during pregnancy

Autor:	L, Luo, T, Ibaragi, M, Maeda, M, Nozawa, T, Kasahara, M, Sakai, Y, Sasaki, K, Tanebe, S, Saito
Rok vydání:	2000
Předmět:	Adult Leukocyte Count Adolescent Pregnancy Blotting Western Interleukin-8 Postpartum Period Cervix Mucus Humans Enzyme-Linked Immunosorbent Assay Female Middle Aged Granulocytes
Zdroj:	American journal of reproductive immunology (New York, N.Y. : 1989). 43(2)
ISSN:	1046-7408
Popis:	We measured interleukin-8 (IL-8) and granulocyte counts in cervical mucus to assess local immunity and parturition.We detected IL-8 by enzyme linked immunosorbent assay (ELISA) and Western blotting. Granulocytes were counted on a slide glass containing mucus from the external cervical os.ELISA and Western blotting revealed IL-8 in cervical mucus from both nonpregnant and pregnant women. There were no significant differences in cervical mucus IL-8 levels or granulocyte counts between follicular, ovulatory, and luteal phases. However, IL-8 and granulocyte counts were significantly decreased after menopause. IL-8 and granulocyte counts were increased significantly during pregnancy, and were further increased after 38 weeks of gestation and at labor. IL-8 levels were significantly correlated with granulocyte counts, based on the study of 678 samples (P0.0001).IL-8 is involved in the increase of cervical granulocytes and in the process of parturition.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::1c04970a03d5715cb8bc8a8b1132955b https://pubmed.ncbi.nlm.nih.gov/10735598 Zobrazit plný text záznamu Plný text