| Autor: |
Jan Claudius, Schwitalla, Johanna, Pakusch, Brix, Mücher, Alexander, Brückner, Dominic Alexej, Depke, Thomas, Fenzl, Chris I, De Zeeuw, Lieke, Kros, Freek E, Hoebeek, Melanie D, Mark |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Cellular and molecular life sciences : CMLS. 79(4) |
| ISSN: |
1420-9071 |
| Popis: |
Absence seizures (ASs) are characterized by pathological electrographic oscillations in the cerebral cortex and thalamus, which are called spike-and-wave discharges (SWDs). Subcortical structures, such as the cerebellum, may well contribute to the emergence of ASs, but the cellular and molecular underpinnings remain poorly understood. Here we show that the genetic ablation of P/Q-type calcium channels in cerebellar granule cells (quirky) or Purkinje cells (purky) leads to recurrent SWDs with the purky model showing the more severe phenotype. The quirky mouse model showed irregular action potential firing of their cerebellar nuclei (CN) neurons as well as rhythmic firing during the wave of their SWDs. The purky model also showed irregular CN firing, in addition to a reduced firing rate and rhythmicity during the spike of the SWDs. In both models, the incidence of SWDs could be decreased by increasing CN activity via activation of the G |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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