Prevention of Contrast-induced Nephropathy in Patients with Chronic Kidney Disease Undergoing Elective Coronary Angioplasty or Angiography with Sodium Potassium Citrate Solution, a Double Blind Randomized Clinical Trial
| Autor: | Ali, Ghorbani, Saeed, Yazdankhah, Mohamad Hasan, Adel, Hamed, Tabesh, Ali Reza, Sattari, Shahab Aldin, Sattari, Habib, Heybar, Shahla, Madjidi |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Aged 80 and over Male Contrast Media Acute Kidney Injury Hydrogen-Ion Concentration Middle Aged Coronary Angiography Sodium Citrate Logistic Models Double-Blind Method Creatinine Potassium Citrate Multivariate Analysis Humans Female Renal Insufficiency Chronic Diuretics Aged Glomerular Filtration Rate |
| Zdroj: | Iranian journal of kidney diseases. 13(3) |
| ISSN: | 1735-8604 |
| Popis: | Contrast-induced nephropathy (CIN) is a frequent complication of contrast exposure. A recent study suggested that Na/K citrate might have a preventive role. We investigated the efficacy of Na/K citrate to prevent CIN in patients with renal dysfunction undergoing coronary intervention.The randomized, double-blind, placebo-controlled trial included 201 patients with estimated creatinine clearance90 mL/ min, randomized to receive oral Na/K citrate plus saline infusion (treatment group, 104 patients) or oral water plus saline infusion (placebo group, 97 patients). CIN was defined as an absolute increase of serum creatinine ≥ 0.5 mg/dL or a relative increase ≥ 25% or a relative decrease of estimated GFR ≥ 25% within 5 days.CIN occurred in 22 patients (12.29%); 10 (11%) in treatment group and 12 (13.6%) in placebo group (P.05). Post-exposure Cr values were not significantly different between the two groups (1.18 ± 0.28 mg/dL in the placebo vs. 1.15 ± 0.29 mg/dL in the treatment group, P.05). CIN-negative patients in the treatment group showed a significantly higher increase in urine pH than that of CIN-positive patients (1.642 ± 0.577 vs. 1.20 ± 0.422, P.05).Na/K citrate solution is not effective for prophylaxis of CIN in patients with renal dysfunction. However, a probable preventive effect might exist in a subgroup of patients with at least 1.6 units increase in urine pH values following Na/K citrate administration. |
| Databáze: | OpenAIRE |
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