| Autor: |
Tong-ling, Wang, Tao, Liu, Shan-miao, Gou, Li, Wang, Wei, Zhou, Chun-you, Wang |
| Rok vydání: |
2012 |
| Předmět: |
|
| Zdroj: |
Zhonghua zhong liu za zhi [Chinese journal of oncology]. 34(5) |
| ISSN: |
0253-3766 |
| Popis: |
To explore the correlation between the expressions of hypoxia inducible factor-1α (HIF-1α) and insulin in pancreatic cancer.HIF-1α and insulin expression was detected by immunohistochemistry in the center and the edge of pancreatic adenocarcinoma specimens of 65 cases. Western blot was used to detect HIF-1α expression and insulin level in the center and the edge of pancreatic adenocarcinoma specimens of 28 cases. The relationship between HIF-1α expression and insulin level in the pancreatic cancer was analyzed.The results of immunohistochemistry and Western blot showed that HIF-1α protein expression was high in both the center and the edge of pancreatic cancers (P0.05), and insulin level was significantly higher at the edge of specimen than that in the center (P0.05). HIF-1α protein and insulin levels were positively correlated at the edge of cancer tissue (r = 0.374, P0.05), but no significant correlation between them in the center of cancerous tissue (r = -0.145, P0.05).Insulin may promote the local invasion and metastasis of pancreatic cancer by up-regulating HIF-1α. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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