| Autor: |
Elzbieta, Mikiciuk-Olasik, Emilia, Wojewoda, Ireneusz, Bilichowski, Małgorzata, Witczak, Bolesław, Karwowski, Małgorzata, Wagrowska-Danilewicz, Olga, Stasikowska |
| Rok vydání: |
2010 |
| Předmět: |
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| Zdroj: |
Acta poloniae pharmaceutica. 67(2) |
| ISSN: |
0001-6837 |
| Popis: |
Due to their high specificity for the hepatobiliary system, iminodiacetic acid derivatives are known to form a class of hepatobiliary agents. In this paper we present new hepatotropic gadolinium complexes to be used as potential MRI contrast agents. Derivatives of N-(2-phenylamine-2-oxoethyl) iminodiacetic acid are introduced as ligands into such complexes. In this way, we hope to achieve a valuable diagnostic tool for investigating of pathological changes in the liver. Stability constants of complexes were determined by potentiometric titration in 0.1 mol L(-1) NaNO3 solution at 20.0 +/- 0.1 degrees C. Stability and selectivity constants were also determined for endogenous metal ions such as Cu2+, Ca2+, and Zn2+ with the use of SUPERQUAD computer program. Acute toxicity of new gadolinium complexes was assessed in mice and histopathology examinations were carried out. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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