| Autor: |
B, Suchanek, P H, Seeburg, R, Sprengel |
| Rok vydání: |
1997 |
| Předmět: |
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| Zdroj: |
Biological chemistry. 378(8) |
| ISSN: |
1431-6730 |
| Popis: |
In the mouse brain, the N-methyl-D-aspartate receptor subunit NR2C (epsilon-3) is mainly detected in the cerebellar granule cells starting from the second week of postnatal life. In order to improve our understanding of molecular mechanisms of this neuron-specific, spatial and temporal gene expression, different promoter fragments were used to control indicator genes in nondifferentiated rat pheochromocytoma (PC12) cells, in human embryonal kidney (HEK293) cells and in transgenic mice. A 400 bp NR2C promoter region upstream of the transcriptional start site was identified as a basal promoter that was negatively regulated possibly by a neuron restrictive silencer element (NRSE) that is localized 664 base pairs downstream from the transcriptional start sites. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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