| Autor: |
Jihyun, Kim, Mihajlo, Novakovic, Sundaresan, Jayanthi, Adonis, Lupulescu, Ēriks, Kupče, J Tassilo, Grün, Klara, Mertinkus, Andreas, Oxenfarth, Harald, Schwalbe, Lucio, Frydman |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Chemphyschem : a European journal of chemical physics and physical chemistry. 23(4) |
| ISSN: |
1439-7641 |
| Popis: |
Hadamard encoded saturation transfer can significantly improve the efficiency of NOE-based NMR correlations from labile protons in proteins, glycans and RNAs, increasing the sensitivity of cross-peaks by an order of magnitude and shortening experimental times by ≥100-fold. These schemes, however, fail when tackling correlations within a pool of labile protons - for instance imino-imino correlations in RNAs or amide-amide correlations in proteins. Here we analyze the origin of the artifacts appearing in these experiments and propose a way to obtain artifact-free correlations both within the labile pool as well as between labile and non-labile |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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