| Autor: |
I, Zebrowska-Lupina, A, Porowska, T, Pietrasiewicz |
| Rok vydání: |
1985 |
| Předmět: |
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| Zdroj: |
Polish journal of pharmacology and pharmacy. 37(6) |
| ISSN: |
0301-0244 |
| Popis: |
The influence of antidepressants: nomifensine, imipramine, amitriptyline and trazodone on the effect of antiparkinsonian agents: trihexyphenidil and L-DOPA + carbidopa mixture (sinemet) in the model of haloperidol catalepsy was investigated in rats. In some experiments deprenyl, a selective MAO-B inhibitor, was used. It was found that antidepressant drugs in doses not influencing haloperidol catalepsy enhanced significantly the anticataleptic effect of trihexyphenidil and L-DOPA + carbidopa. The most effective in the interaction with both antiparkinsonian agents was nomifensine. Imipramine and trazodone potentiated anticataleptic effect of L-DOPA + carbidopa more strongly than those of trihexyphenidil. The most potent anticataleptic effect was observed after combined treatment of rats with deprenyl and L-DOPA + carbidopa. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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