| Autor: |
Erfan, Saatchian, Sina, Ehsani, Abolfazl, Sarikhani, Habib, Ghaznavi, Alireza, Montazerabadi, Ali, Shakeri-Zadeh |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Lasers in medical science. 37(1) |
| ISSN: |
1435-604X |
| Popis: |
Nanotechnology-based photothermal therapy (NPTT) is a new emerging modality of cancer therapy. To have the right prediction and early detection of response to NPTT, it is necessary to get rapid feedback from a tumor treated by NPTT procedure and stay informed of what happens in the tumor site. We performed this study to find if proton magnetic resonance spectroscopy (1H-MRS) can be well responsive to such an imperative requirement. We considered various treatment groups including gold nanoparticles (AuNPs), laser, and the combination of AuNPs and laser (NPTT group). Therapeutic effects on CT26 colon tumor-bearing BALB/c mice were studied by looking at alterations that happened in 1H-MRS signals and tumor size after conducting treatment procedures. In MRS studies, the alterations of choline and lipid concentrations and their ratio were investigated. Having normalized the metabolite peak to water peak, we found a significant decrease in choline concentration post-NPTT (from (1.25 ± 0.05) × 10 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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