| Autor: |
O L, Potyl'chanskaia, R A, Araviĭskiĭ |
| Rok vydání: |
1987 |
| Předmět: |
|
| Zdroj: |
Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology. 32(10) |
| ISSN: |
0233-7525 |
| Popis: |
It was shown that combined use of the polyene antibiotic amphoglucamine (AMG) and 5-fluorocytosine (5-FC), rifampicin, or methacycline was much more efficient in therapy of experimental generalized candidiasis. Combination of AMG with 5-FC or rifampicin proved to be the most favourable. The use of these combinations resulted in a 7-8-fold increase in the average lifespan of experimental animals, markedly increased their survival and lowered contamination of the internal organs with the fungus. Combination of AMG with 5-FC resulted in complete healing of experimental mice by the end of the treatment. Summation of the antifungal action of the drugs provided the required effect with the polyene dose 2 times lower than the therapeutic one. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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