Astaxanthin production in a model cyanobacterium Synechocystis sp. PCC 6803

Autor: Naoya, Shimada, Yukiko, Okuda, Kaisei, Maeda, Daisuke, Umeno, Shinichi, Takaichi, Masahiko, Ikeuchi
Rok vydání: 2020
Předmět:
Zdroj: The Journal of general and applied microbiology. 66(2)
ISSN: 1349-8037
Popis: Heterologous production of a useful carotenoid astaxanthin was achieved in a cyanobacterium Synechocystis sp. PCC 6803 with the aid of marine bacterial genes. Astaxanthin and its intermediates emerged at high levels, whereas β-carotene and zeaxanthin disappeared in the strain. Total carotenoid accumulation was nearly two fold compared with wild type. The astaxanthin-producing strain was capable of only growing heterotrophically, which was likely due to the absence of β-carotene. Further enhanced accumulation was pursued by gene overexpression for possible rate-limiting steps in the biosynthesis pathway.
Databáze: OpenAIRE