Reduction of Zika virus infectivity in platelet concentrates after treatment with ultraviolet C light and in plasma after treatment with methylene blue and visible light

Autor:	Jesse J, Fryk, Denese C, Marks, Jody, Hobson-Peters, Daniel, Watterson, Roy A, Hall, Paul R, Young, Stefan, Reichenberg, Frank, Tolksdorf, Chryslain, Sumian, Ute, Gravemann, Axel, Seltsam, Helen M, Faddy
Rok vydání:	2017
Předmět:	Blood Platelets Methylene Blue Plasma Light Limit of Detection Ultraviolet Rays Zika Virus Infection Humans Virus Inactivation Zika Virus
Zdroj:	Transfusion. 57(11)
ISSN:	1537-2995
Popis:	Zika virus (ZIKV) has emerged as a potential threat to transfusion safety worldwide. Pathogen inactivation is one approach to manage this risk. In this study, the efficacy of the THERAFLEX UV-Platelets system and THERAFLEX MB-Plasma system to inactivate ZIKV in platelet concentrates (PCs) and plasma was investigated.PCs spiked with ZIKV were treated with the THERAFLEX UV-Platelets system at 0.05, 0.10, 0.15, and 0.20 J/cmTreatment of PCs with THERAFLEX UV-Platelets system resulted in a mean of 5 log reduction in ZIKV infectivity at the standard UVC dose (0.20 J/cmOur study demonstrates that the THERAFLEX UV-Platelets system and THERAFLEX MB-Plasma system can reduce ZIKV infectivity in PCs and pooled plasma to the detection limit of the assays used. These findings suggest both systems have the capacity to be an effective option to manage potential ZIKV transfusion transmission risk.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::1b148c1a6f08dbbd09f49f9871d320df https://pubmed.ncbi.nlm.nih.gov/28718518 Zobrazit plný text záznamu Plný text