| Autor: |
V, Tamassia, M G, Jannuzzo, E, Moro, S, Stegnjaich, W, Groppi, F B, Nicolis |
| Rok vydání: |
1984 |
| Předmět: |
|
| Zdroj: |
International journal of clinical pharmacology research. 4(3) |
| ISSN: |
0251-1649 |
| Popis: |
Indoprofen, a non-steroidal analgesic and antiinflammatory drug whose activity and safety in man have been established in a large number of studies, has an asymmetric carbon atom and can therefore occur as either the (+) or the (-) enantiomer. As it has been shown that its pharmacological effects are almost entirely due to the (+) isomer (d-indoprofen), some pharmacokinetic properties of the latter have been studied in man in comparison with the racemic mixture given by oral administration, d-indoprofen is cleared from plasma and excreted in urine (as unchanged plus conjugated drug) at a slower rate than l-indoprofen. Moreover, no stereospecific inversion of d-indoprofen to the inactive enantiomer occurs after either single or repeated (one week) administration. The pharmacokinetic behaviour of d-indoprofen in the human organism appears to be the same after administration of the racemic form or of the dextro-enantiomer, when the latter is given at half the dose. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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