[Effects of nitroxyl radicals on pathogenic properties of herpesvirus (the spin-label technique in the study of virus-macrophage interactions)]

Autor: N V, Gorbunov, R A, Nasyrov, A N, Erin, V P, Ivanova, L Iu, Taros
Rok vydání: 1992
Předmět:
Zdroj: Biulleten' eksperimental'noi biologii i meditsiny. 113(6)
ISSN: 0365-9615
Popis: The effect of various concentrations of both methyl ether of 5-doxyl-stearic acid (M5DS) and 4-maleimido-TEMPO (4MT) on the pathogenicity of herpes simplex virus (HSV-1) was studied. It is known that the reagents modify the lipid matrix and the proteins of virion envelope. The decrease of the HSV-1 pathogenicity was shown when using the concentration of reagents more 5 x 10(-5) M. HSV-1 having high pathogenicity and cytotoxicity was obtained when the concentrations of the reagents were less 5 x 10(-5) M.
Databáze: OpenAIRE