| Autor: |
J, Krassowski, P, Szulc, J, Kurta, W, Jeske, S, Zgliczyński |
| Rok vydání: |
1992 |
| Předmět: |
|
| Zdroj: |
Endokrynologia Polska. 43(3) |
| ISSN: |
0423-104X |
| Popis: |
The aim of the study was the evaluation of growth hormone secretion under physiologic conditions in two groups of type I diabetics: responding and nonresponding to TRH stimulation. Both groups matched for age and metabolic control of diabetes were studied during 24-hours and after GHRH stimulation. The whole diabetic group (n = 18) showed circadian rhythm of GH secretion with mesor value of 4.03 micrograms/l. TRH-responders had lower mesor GH value than TRH-nonresponders: 3.53 vs. 5.32, p0.05. GH response to GHRH was almost identical in both groups. C-peptide level was lower in TRH-responders: 0.16 vs. 0.56 microgram/l, p0.05. No correlation was found between growth hormone response and HbA1 and C-peptide levels. It is concluded that type I diabetics responding to TRH stimulation are characterized by lower mean 24-hour GH levels and lower C-peptide values. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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