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Background: Medical education was widely affected by the Coronavirus disease 2019 (COVID-19) pandemic. Long-distance learning was implemented over the traditional educational paradigm. Clinical clerkships were canceled, and evaluation methods were altered. This study aims to assess this multifaceted impact on the Greek undergraduate medical community. Methods: A cross-sectional survey study was conducted. All undergraduate medical students at Greek Universities were addressed using social media. The data were post-stratified according to the population’s male-to-female ratio and underwent descriptive and inferential statistical analysis. Associations were determined using chi-square and Fisher’s exact test. A linear regression model was developed to investigate the factors that contributed to the overall impact of the pandemic on medical education. Results: A total of 905 responses were analyzed, representing 9.8 % of Greece’s medical students. Most reported decreased duration of laboratory (n =711, 78.5 %) and clinical (n =526, 96.7 %) practice. The majority stated that their ability to perform practical skills was affected negatively (n =805, 89.0 %). The impact on student’s education was positively associated with their psychological impact. Therefore, a more negative effect on the student’s education was observed on those whose psychology was affected more negatively [β =0.49, 95 % confidence interval (CI): 0.40, 0.58, p |