| Autor: |
Leila, Rezaie Shirmard, Mahdieh, Ghofrani, Nika, Bahari Javan, Samane, Bayrami, Abdollah, Tavassoli, Amir, Rezaie, Mohsen, Amini, Abbas, Kebriaee-Zadeh, Mohammad-Reza, Rouini, Rassoul, Dinarvand, Morteza, Rafiee-Tehrani, Farid Abedin, Dorkoosh |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Drug development and industrial pharmacy. 46(2) |
| ISSN: |
1520-5762 |
| Popis: |
Uncontrolled distribution of nanoparticles (NPs) within the body can significantly decrease the efficiency of drug therapy and is considered among the main restrictions of NPs application. The aim of this study was to develop a depot combination delivery system (CDS) containing fingolimod loaded poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) NPs dispersed into a matrix of oleic acid-grafted-aminated alginate (OA-g-AAlg) to minimize the nonspecific biodistribution (BD) of PHBV NPs. OA-g-AAlg was synthesized in two step; First, Alg was aminated by using adipic dihydrazide (ADH). The degree of hyrazide group substitution of Alg was determined by trinitro-benzene-sulfonic acid (TNBS) assay. Second, OA was attached to AAlg through formation of an amide bond. Chemical structure of OA-g-AAlg was confirmed with FTIR and HNMR spectroscopy. Furthermore, rheological properties of OA-g-AAlg with different grafting ratios were evaluated. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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