Infusion of dendritic cells pulsed with HLA-A2-specific prostate-specific membrane antigen peptides: a phase II prostate cancer vaccine trial involving patients with hormone-refractory metastatic disease
| Autor: | G P, Murphy, B A, Tjoa, S J, Simmons, J, Jarisch, V A, Bowes, H, Ragde, M, Rogers, A, Elgamal, G M, Kenny, O E, Cobb, R C, Ireton, M J, Troychak, M L, Salgaller, A L, Boynton |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Aged 80 and over Glutamate Carboxypeptidase II Male Vaccines Synthetic Prostatic Neoplasms Bone Neoplasms Carboxypeptidases Dendritic Cells Middle Aged Cancer Vaccines Hormones Treatment Outcome Antigens Neoplasm Antigens Surface HLA-A2 Antigen Humans Infusions Intravenous Radionuclide Imaging Aged |
| Zdroj: | The Prostate. 38(1) |
| ISSN: | 0270-4137 |
| Popis: | A phase II trial was conducted to assess the efficacy of infusions of dendritic cells (DC) and two HLA-A2-specific PSMA peptides (PSM-P1 and -P2). This report describes thirty three subjects with hormone-refractory metastatic prostate cancer without prior vaccine therapy history who were evaluated and reported as a group.All subjects received six infusions of DC pulsed with PSM-P1 and -P2 at six week intervals. Clinical monitoring was conducted pre-, during, and post- phase II study. Data collected include: complete blood count, bone and total alkaline phosphatase, prostate markers, physical examination, performance status, bone scan, ProstaScint scan, chest x-ray, as well as assays to monitor cellular immune responses.Six partial and two complete responders were identified in the phase II study based on NPCP criteria, plus 50% reduction of prostate-specific antigen (PSA), or resolution in previously measurable lesions on ProstaScint scan.Over 30% of study participants in this group showed a positive response at the conclusion of the trial. This study suggested that DC-based cancer vaccines may provide an alternative therapy for prostate cancer patients whose disease no longer responds to hormone therapy. |
| Databáze: | OpenAIRE |
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