| Autor: |
O P, Siniagina, O A, Lapchinskaia, M F, Lavrova-Balashova, T P, Nesterova, V I, Ponomarenko |
| Rok vydání: |
1980 |
| Předmět: |
|
| Zdroj: |
Antibiotiki. 25(12) |
| ISSN: |
0003-5637 |
| Popis: |
The organism producing an aminoglycoside antibiotic complex was subjected to selection with a purpose of obtaining a strain producing tobramycin. Spontaneous and gamma-radiation-induced variation of the strains obtained as a result of a step-wise selection of the tobramycin-producing organism was studied. Correlation between the antibiotic activity levels and morphological features of these strains was shown. 8 physiological groups of mutants were differentiated and characterized as dependent on the ratio of the components in the aminoglycoside antibiotic complex produced by them. A highly productive strain 3406 was selected. The level of tobramycin synthesis by this strain is 10 times higher than that of the initial culture. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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