| Autor: |
E, Minkov, N, Lambov, D, Kirchev, I, Bantutova, J, Tencheva |
| Rok vydání: |
1985 |
| Předmět: |
|
| Zdroj: |
Die Pharmazie. 40(4) |
| ISSN: |
0031-7144 |
| Popis: |
The influence of the suppository base and drug solubility on the release an absorption of phenobarbital and phenobarbital-sodium from model suppositories was investigated. It was established that the pharmaceutical and biological availability of phenobarbital is higher from a hydrophilic base because of its improved solubility. The rate and the degree of release of phenobarbital-sodium are more significant from lipophilic bases. The bioavailability of two drug forms-phenobarbital and phenobarbital-sodium--is almost equal after rectal and oral administration. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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