| Autor: |
Kioomars, Saliminejad, Shahrzad, Soleymani Fard, Hamid Reza, Khorram Khorshid, Marjan, Yaghmaie, Habibollah, Mahmoodzadeh, Seyed Asadollah, Mousavi, Seyed Hamidollah, Ghaffari |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Avicenna Journal of Medical Biotechnology |
| ISSN: |
2008-2835 |
| Popis: |
Background: Most of Gastric Cancer (GC) patients are diagnosed at an advanced stage with poor prognosis. Hypermethylations of several tumor suppressor genes in cell-free DNA of GC patients have been previously reported. In this study, an attempt was made to investigate the methylation status of P16, RASSF1A, RPRM, and RUNX3 and their potentials for early diagnosis of GC. Methods: Methylation status of the four tumor suppressor genes in 96 plasma samples from histopathologically confirmed gastric adenocarcinoma patients (Stage I–IV) and 88 healthy controls was determined using methylation-specific PCR method. Receiver operating characteristic curve analysis was performed and Area Under the Curve (AUC) was calculated. Two tailed p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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