| Autor: |
Taoda, Shi, Christopher J, Zerio, Jared, Sivinski, Andrew J, Ambrose, Kohlson T, Moore, Thomas, Buckley, Lynn, Kaneko, Mae, Zhang, Donna D, Zhang, Eli, Chapman |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
European J Org Chem |
| ISSN: |
1434-193X |
| Popis: |
A Na(2)HPO(4)-catalyzed four-component reaction between a ketone, malononitrile, S(8) and formamide has been realized for the first time. This reaction provides a concise approach to thieno[2,3-d]pyrimidin-4-amines, previously requiring 5 steps. The utility of this reaction was validated by preparing a multi-targeted kinase inhibitor and an inhibitor of the NRF2 pathway with excellent atom- and step-economy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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