| Autor: |
P, Calés, F, Oberti, J L, Payen, S, Naveau, D, Guyader, P, Blanc, A, Abergel, P, Bichard, J M, Raymond, V, Canva-Delcambre, D, Vetter, D, Valla, M, Beauchant, A, Hadengue, B, Champigneulle, J P, Pascal, T, Poynard, D, Lebrec |
| Rok vydání: |
1999 |
| Předmět: |
|
| Zdroj: |
European journal of gastroenterologyhepatology. 11(7) |
| ISSN: |
0954-691X |
| Popis: |
Beta-blockers have been shown to reduce portal pressure in patients with cirrhosis and limit the development of portosystemic shunts in portal hypertensive animals. Thus, a randomized double-blind trial was conducted to evaluate propranolol in the prevention of the development of large oesophageal varices in patients with cirrhosis without varices or with small varices.One hundred and two patients received long-acting propranolol (160 mg/day) and 104 patients received a placebo. At inclusion, there was no significant difference between the two groups in terms of clinical characteristics or biochemical tests. At 2 years, the size of varices was estimated on video recordings.One-third of the patients were lost to follow-up, and 95%/97% of the remaining patients were compliant in the propranolol and placebo groups, respectively. At 2 years, the proportion of patients with large varices was 31% in the propranolol group and 14% in the placebo group (P0.05). Three and four patients bled in the propranolol and placebo groups, respectively, and nine and ten died, respectively.This trial suggests that propranolol administration cannot be recommended for the prevention of the development of large oesophageal varices in patients with cirrhosis; thus other studies are needed in selected subgroups of patients. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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