| Autor: |
Priscilla, Kheddo, Jack E, Bramham, Rebecca J, Dearman, Shahid, Uddin, Christopher F, van der Walle, Alexander P, Golovanov |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Molecular pharmaceutics. 14(8) |
| ISSN: |
1543-8392 |
| Popis: |
Liquid-liquid phase separation (LLPS) of monoclonal antibody (mAb) formulations involves spontaneous separation into dense (protein-rich) and diluted (protein-lean) phases and should be avoided in the final drug product. Understanding the factors leading to LLPS and ways to predict and prevent it would therefore be highly beneficial. Here we describe the link between LLPS behavior of an IgG1 mAb (mAb5), its solubility, and parameters extracted using |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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