| Autor: |
T P, Saburova, O A, Lapchinskaia, O P, Siniagina, E M, Trutneva, N A, L'vova |
| Rok vydání: |
1977 |
| Předmět: |
|
| Zdroj: |
Antibiotiki. 22(12) |
| ISSN: |
0003-5637 |
| Popis: |
A total of 351 auxotrophic mutants with different antibiotic activity, including several mutants with activity higher than that of the parent prototrophic strains were obtained under the effect of gamma-rays from 3 prototrophic strains of Act. coeruleorubidus. It was shown that most of the auxotrophic mutants did not preserve the property of biochemical insufficiency on passages on complete media. A mutant strain 1059-32 with activity 2 times higher than that of the prototrophic strain 2-39 and the parent auxotrophic culture was obtained from the revertants. Requirements in 29 growth factors including 17 amino acids, 4 nitrous bases, 8 vitamins and coenzymes were determined in 46 stable auxotrophic mutants isolated. The effect of the specific and non-specific growth factors on the culture antibiotic production was studied. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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