Serum vascular endothelial growth factor (VEGF) in the normal menstrual cycle: association with changes in ovarian and uterine Doppler blood flow

Autor:	R, Agrawal, G S, Conway, P, Sladkevicius, N N, Payne, J, Bekir, S, Campbell, S L, Tan, H S, Jacobs
Rok vydání:	1999
Předmět:	Adult Vascular Endothelial Growth Factor A Analysis of Variance Lymphokines Vascular Endothelial Growth Factors Ovary Uterus Endothelial Growth Factors Regional Blood Flow Ultrasonography Doppler Pulsed Humans Female Ultrasonography Doppler Color Menstrual Cycle
Zdroj:	Clinical endocrinology. 50(1)
ISSN:	0300-0664
Popis:	To investigate whether changes in circulating serum vascular endothelial growth factor (VEGF) concentrations during the menstrual cycle are associated with changes in blood flow within the ovaries and uterus.Serum VEGF concentrations were measured and pulsed and colour Doppler blood flow waveforms recorded within the ovarian stroma and uterine arteries during the early follicular, the immediate preovulatory and the mid-luteal phases of the menstrual cycle of 14 healthy women.Mean (+/- SD) serum VEGF concentrations rose from 2.44 +/- 0.1 ng/ml in the early follicular phase to 3 +/- 0.8 ng/ml in the pre-ovulatory phase and to 4.4 +/- 0.9 ng/ml in the mid-luteal phase (P0.0001) of the menstrual cycle. Mean peak systolic blood flow velocity (PSV) and time-averaged maximum flow velocity (TAMXV) were higher within the ovarian stroma of the ovary bearing the dominant follicle and the uterine arteries in the pre-ovulatory and mid-luteal phase than in the same sites during the early follicular phase of the menstrual cycle. PSV rose significantly from the early follicular phase (11 +/- 6 cm/s) to 14 +/- 4 cm/s in the pre-ovulatory phase and further in the mid-luteal phase (26 +/- 7 cm/s, P = 0.0001). Within the uterine arteries, mean PSV rose significantly from 28 +/- 9 cm/s in the early follicular phase to 31 +/- 8 cm/s in the pre-ovulatory phase and further in the mid-luteal phase (44 +/- 11 cm/s, P0.005). Serum VEGF correlated with serum progesterone concentrations in the luteal phase (r = 0.85, P0.001), with serum oestradiol concentrations in the early follicular (r = 0.67, P = 0.009), pre-ovulatory (r = 0.57, P = 0.03) and luteal phases (r = 0.68, P0.005) and with serum testosterone in the early follicular phase (r = 0.63, P = 0.01).Cyclical changes in serum vascular endothelial growth factor concentrations are associated with coincident changes in ovarian and uterine blood flow.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::19c4a6f282592e7c00144981f097bd0f https://pubmed.ncbi.nlm.nih.gov/10341862 Zobrazit plný text záznamu Plný text