Allosteric modulation of nicotinic and GABA

Autor:	Ryan F, Yoshimura, Minhtam B, Tran, Derk J, Hogenkamp, Narielle L, Ayala, Timothy, Johnstone, Andrew J, Dunnigan, Timothy K, Gee, Kelvin W, Gee
Rok vydání:	2017
Předmět:	Male Behavior Animal alpha7 Nicotinic Acetylcholine Receptor Autism Spectrum Disorder Mice Transgenic Isoxazoles Motor Activity Receptors GABA-A Grooming Mice Inbred C57BL Disease Models Animal Allosteric Regulation Animals Humans Anilides Social Behavior
Zdroj:	Neuropharmacology. 126
ISSN:	1873-7064
Popis:	Autism spectrum disorder (ASD) is associated with two core symptoms (social communication deficits and stereotyped repetitive behaviors) in addition to a number of comorbidities. There are no FDA-approved drugs for the core symptoms and the changes that underlie these behaviors are not fully understood. One hypothesis is an imbalance of the excitation (E)/inhibition (I) ratio with excessive E and diminished I occurring in specific neuronal circuits. Data suggests that both gamma-aminobutyric acid
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::19c26d53d23b86f3373c730a10c7b6d5 https://pubmed.ncbi.nlm.nih.gov/28842344 Zobrazit plný text záznamu Full Text from ScienceDirect